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Methylene Blue: From Alzheimer's to Zika?

The Health Benefits of Methylene Blue is Good News in the Treatment of the Long Term Effects of SARS-CoV-2 Including Brain Fog, Mental Decline, and Depression.

From: Dr. Joseph Mercola's Deep Roots at Home Published: Jun 16, 2022; Modified: Nov 27, 2022

For Providers; 30 minute read. Embedded video: approx. 1:42 mins.

Besides totally inactivating HIV-1, Hepatitis A and C, and the Ebola and Zika viruses, Methylene Blue is scientifically proven to be neuroprotective and help restore/reset brain function in people with Alzheimer’s, Parkinson’s, bipolar, depression and more.

Existing ‘approved’ drugs for dementia obviously don’t work or they would be curing people and the disease would disappear.

Methylene Blue is the parent molecule for hydroxychloroquine, the off-patent drug commonly used to treat not only malaria but also “The Great Flu”. Until antibiotics came along, it was commonly used to treat urinary tract infections (which still works, btw) at low doses mentioned below. It’s also used as an antiviral agent in blood transfusions.

To this day, Methylene Blue (MB) is found in every hospital worldwide for metabolic poisons that interferes with oxygen transport. If you’re admitted for carbon monoxide or cyaninde poisoning, you’ll receive methylene blue intravenously. It’s the only known antidote.

Studies have demonstrated Methylene Blue is an extremely effective antidepressant. You likely don’t know about it because very this affordable substance would put the mental health industry out of business. And it doesn’t have the nasty side-effects of Paxil or other antidepressants.

In this video, Dr. Mercola and Dr. Francisco Gonzalez-Lima cover why Big Pharma doesn’t want us to know about Methylene Blue or how to use it. If you want to care for your family outside of the present medical paradigm, this would be something to pay attention to and have in your medicine toolkit.

[Gonzalez-Lima is the top expert on methylene blue, which helps mitochondrial respiration and improves brain energy metabolism that can truly prevent neurodegeneration and improve cognitive performance. Our group was the first to map the effects of methylene blue in the brain of humans and show its effects on improving brain metabolism, blood flow and memory function.”]

Low doses of MB work well as a nootropic, but high doses DO NOT. See the low dose chart below.

Quick list of important neurological diseases Methylene Blue addresses

Methylene Blue for Bipolar Disorder:

"MB in the Treatment of Neuropsychiatric Disorders." Conclusion: “Use of methylene blue in bipolar disorder led to a better stabilization and a reduction in residual symptoms of the illness.” Another study here. See MB May Help Bipolar Depression.

Methylene Blue for Depression

"A Controlled Trial of MB in Severe Depressive Illness." Conclusion: “Methylene blue at a dose of 15 mg/day appears to be a potent antidepressant..”

"The Prophylactic Effect of MB in Manic-Depressive Psychosis." Conclusion: “During the year the patients were treated with methylene blue at 300 mg/day, they were significantly less depressed than during the year on 15 mg/day.” The Journal of Neurotrauma reports that methylene blue has an antidepressant effect in mice with traumatic brain injury (TBI).

MB Resists Alzheimer’s, Dementia, Parkinson’s, and Huntington’s Diseases

"MB and Alzheimer’s Disease." Conclusion: MB is known to reduce the formations of amyloid plaques and neurofibrillary tangles and to repair impairments in mitochondrial function and cellular metabolism. It also shows promise in treating Parkinson’s and Huntington’s diseases... (source)

MB Improves Memory:

"Neurometabolic Mechanisms for Memory Enhancement and Neuroprotection of MB." Conclusion: “..Methylene Blue is neuroprotective… a safe intervention for the treatment of acute and chronic conditions with neurodegeneration and memory impairment.”

"Functional MR Imaging of the Effects of MB in the Human Brain." Conclusion: A single oral dose of MB improved memory retrieval by 7% and increased MRI-based responses in areas of the brain that control short-term memory and attention.” More supporting studies here, here, here, and here.

MB Boosts Acetylcholine Important for Neuroplasticity

MB inhibits problematic acetylcholinesterase activity; the outcome is increased levels of acetylcholine. Acetylcholine’s function in the brain is critical for encoding new memories, reasoning, concentration, cognition, and growth of new synapses (neuroplasticity). Lack of acetylcholine can result in diseases like ADD, ADHD and Alzheimer’s. MB improves serotonin and norepinephrine affecting anxiety, depression and memory.

MB Increases Mitochondrial Energy:

Methylene Blue assists brain cell respiration by increasing oxygen. And donating electrons to the electron transport chain within mitochondria. This same process is used to create ATP within mitochondria from the food you eat. So MB contributes to this energy-production process. Increasing cellular energy positively effects mood and memory.

MB is Neuroprotective:

Methylene Blue is a potent antioxidant. When damaging reactive oxygen species are produced inside mitochondria, the first free radical that is formed inside a cell is superoxide. MB will bind to superoxide and reduce it to water. It stops the oxidative cascade at its very beginning, before it gets a chance to do damage.

How to Take Methylene Blue

Methylene Blue

Make sure to get it from a trusted source like Dr. Lily David Institute, directly from their on-premise formulary, or other reputable sources. Dr. Lily's product is 0.5 mg./drop and batch tested for purity.

Dr. Lily David's prescribes very low dose Methylene Blue supplementation (0.5 mg to 1 mg/kg of bodyweight/day) provides many life-enhancing effects, while very high doses are harmful. With MB, less is more.


Body Weight: 50 kg/110 lbs: 0.5 mg/kg dose = 25 mg/day or 50 drops/day

Body Weight: 55 kg/121 lbs: 0.5 mg/kg dose = 27.5 mg/day or 55 dr/day

Body Weight: 60 kg/132 lbs: 0.5 mg/kg dose = 30 mg/day or 60 drops/day

Body Weight: 65 kg/143 lbs: 0.5 mg/kg dose = 32.5 mg/day or 65 dr/day

Body Weight: 70 kg/154 lbs: 0.5 mg/kg dose = 35 mg/day or 70 drops/day

Body Weight: 75 kg/165 lbs: 0.5 mg/kg dose = 37.5 mg/day or 75 dr/day

Body Weight: 80 kg/176 lbs: 0.5 mg/kg dose = 40 mg/day or 80 drops

Body Weight: 85 kg/187 lbs: 0.5 mg/kg dose = 42.5 mg/day or 85 dr/day

Body Weight: 90 kg/198 lbs: 0.5 mg/kg dose = 45 mg/day or 90 drops/day

Body Weight: 95 kg/209 lbs: 0.5 mg/kg dose = 47.5 mg/day or 95 dr/day

Body Weight: 100 kg/220 lbs: 0.5 mg/kg dose = 50 mg/day or 100 drops/day

How To Make It NOT SO BLUE

(Jacque’s note: I personally consume 5 drops of this Methylene Blue into lemon water (and you can add buffered sodium ascorbate powder, too) both AM and PM, and the blue color lessens dramatically. That is a total of 10 drops or 5 mg/day. Very low doses like this are discussed at 1:02:30 in the video above. I use a straw, swish with pure water afterward and have not had stained teeth. Urine will be blue-green-tinged, and following that is helpful for titration; tells you when your levels are low again. The half-life is 12-13 hours. Find our personal experience with early dementia prion disease here – and how we have fought it and won. We only recently added MB.)


Do not use Methylene Blue if you have a G6PD deficiency, a liver or kidney disorder, if you use 5-HTP or St. John’s Wort, or if you are pregnant or breastfeeding.

NOTE: Side effects with MB are very rare when doses are under 2 mg/kg. Dr. Lily David's prescribes a gradual therapeutic dosing starting with just drops per day, up to .5mg/kg at maximum dosing.

Monoamine Oxidase (MAOI) inhibition becomes a big problem over 2 mg/kg of MB. So if you are using antidepressants or anti-anxiety medications that affect dopamine or serotonin, you should NOT use Methylene Blue over 2 mg./kg.

In the above referenced video, at 1:33:30, we find Mayo Clinic said there is “NO contraindication for oral MB with SSRIs”.

Closing Statement

While Methylene Blue is effective in treating Alzheimer's, Anxiety, Depression, Bi-Polar, and Dementia—its functions also help support memory, brain fog, neuroplasticity, and mitochondrial energy. But the punchline is with all these therapeutic benefits, doctors who treat the long term damage of the SARS-CoV-2 and related diseases are realizing the incredible effectiveness of Methylene Blue on the symptoms, drastically reducing the damage.

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